Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Consumption of traditional sardinian fermented milk promotes changes in the rat gut microbiota composition and functions.

BMC microbiology·2026
Same author

The effects of time-restricted feeding on early phases of carcinogenesis in rat liver and colon.

Frontiers in nutrition·2026
Same author

Consumption of traditional Sardinian fermented milk promotes changes in the rat gut microbiota composition and functions.

BMC microbiology·2025
Same author

Teaching Gentle Medicine.

Journal of internal medicine·2025
Same author

Dietary Rhythms and MASLD-Related Hepatocellular Carcinoma.

Cancers·2024
Same author

Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement.

medRxiv : the preprint server for health sciences·2024

Related Experiment Video

Updated: Jul 13, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

The evolving concept of tumor microenvironments.

Ezio Laconi1

  • 1Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Patologia Sperimentale, Università di Cagliari, 09125 Cagliari, Italy. elaconi@unica.it

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|July 11, 2007
PubMed
Summary

The cancer microenvironment plays a crucial role in tumor development. This review distinguishes between the tissue microenvironment and the tumor microenvironment, highlighting their sequential roles in cancer progression.

More Related Videos

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

Related Experiment Videos

Last Updated: Jul 13, 2026

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • The tumor microenvironment's role in cancer development is increasingly recognized.
  • A distinction is emerging between the tissue microenvironment and the tumor microenvironment.
  • These microenvironments play sequential and complementary roles in neoplasia.

Purpose of the Study:

  • To review data distinguishing between the tissue and tumor microenvironments.
  • To elucidate the distinct roles of these microenvironments in cancer pathogenesis.
  • To discuss implications for managing preneoplastic and neoplastic lesions.

Main Methods:

  • Literature review of existing data on cancer microenvironments.
  • Analysis of the sequential roles of tissue and tumor microenvironments.
  • Discussion of the biological characteristics of the tumor microenvironment.

Main Results:

  • Two distinct microenvironments are identified: the tissue microenvironment and the tumor microenvironment.
  • Tissue microenvironment alterations promote clonal expansion of preneoplastic cells.
  • The tumor microenvironment, characterized by hypoxia and acidosis, facilitates tumor progression.

Conclusions:

  • The tissue and tumor microenvironments act sequentially in cancer development.
  • Understanding this distinction is vital for cancer pathogenesis and management.
  • This framework aids in comprehending preneoplastic and neoplastic lesion progression.