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Updated: Feb 18, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
[Treatment of neurogenic detrusor hyperactivity: enterocystoplasty]
X Game1, G Karsenty, E Chartier-Kastler
1Service d'urologie, Centre hospitalo-universitaire de Toulouse, France. game.x@chu-toulouse.fr
Abstract:
The importance of a good capacity bladder reservoir able to fill at low pressure has now been clearly established. These properties have a double advantage: they ensure urinary continence and prevent damage to the upper urinary tract. In the case of failure of the various medical treatments, including botulinum toxin injections, surgical bladder augmentation can be considered, especially in the presence of poor bladder compliance. The authors present the technical details of bladder augmentation by enterocystoplasty or by alternative techniques and their medium- and long-term results, and define the postoperative surveillance of this type of surgery.
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The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...

