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Ketoprofen poly(lactide-co-glycolide) physical interaction.

Paolo Blasi1, Aurélie Schoubben, Stefano Giovagnoli

  • 1Department of Chemistry and Technology of Drugs, University of Perugia, Perugia, Italy. kaolino@unipg.it

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Ketoprofen (KET) acts as a plasticizer for poly(lactic-co-glycolic acid) (PLGA) by forming hydrogen bonds, lowering its glass transition temperature. This interaction enhances polymer chain mobility and drug compatibility.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Pharmaceutical Science

Background:

  • Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer in drug delivery systems.
  • Understanding drug-polymer interactions is crucial for optimizing drug release profiles and material properties.

Purpose of the Study:

  • To elucidate the interaction between ketoprofen (KET) and PLGA leading to polymer plasticization.
  • To investigate the effect of KET on the glass transition temperature (Tg) of PLGA.
  • To explore the role of hydrogen bonding in KET-PLGA interactions.

Main Methods:

  • Solvent casting of PLGA films with varying KET concentrations.
  • Characterization using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR).
  • Comparison of experimental Tg values with theoretical predictions from Fox and Gordon-Taylor/Kelley-Bueche equations.

Main Results:

  • KET demonstrated a biphasic plasticizing effect in both end-capped and uncapped PLGA.
  • PLGA Tg decreased to approximately 23°C at 20-35% KET content; higher concentrations led to KET crystallization.
  • FTIR analysis confirmed hydrogen bonding between KET's carboxylic group and PLGA's carbonyl groups, explaining the observed Tg depression.

Conclusions:

  • Hydrogen bonding between KET and PLGA is the primary mechanism for KET's plasticizing effect.
  • KET acts as a lubricant, reducing polymer chain interactions and increasing chain mobility.
  • This interaction is key to understanding KET's behavior within PLGA matrices for potential pharmaceutical applications.