Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pregnancy in IgA nephropathy.

S Abe1

  • 1Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Kidney International
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Pregnancy outcomes for women with IgA nephropathy are generally good if blood pressure is normal and kidney function (GFR) exceeds 70 ml/min. Improved care in the 1980s significantly reduced adverse pregnancy events.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A chimeric analog of human and salmon calcitonin eliminates antigenicity and reduces gastrointestinal disturbances.

Endocrinology·1992
Same author

[Activity of Enterococcus faecalis (FK-23) preparation as a biological response modifier].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·1992
Same author

Simple in vivo bioassay without radioisotopes for recombinant human erythropoietins.

Biologicals : journal of the International Association of Biological Standardization·1992
Same author

In vivo biological activities of recombinant human erythropoietin analogues produced by CHO cells, BHK cells and C127 cells.

Biologicals : journal of the International Association of Biological Standardization·1992
Same author

Application of anti-seminal gamma-glutamyl transpeptidase monoclonal antibody to forensic science.

Nihon hoigaku zasshi = The Japanese journal of legal medicine·1992
Same author

Functionalized, probe-containing, latex nanospheres.

Analytical biochemistry·1992
Same journal

Why current evidence does not support routine C5 inhibition in STEC-HUS.

Kidney international·2026
Same journal

Beyond galactose deficiency: redefining pathogenic IgA in IgA nephropathy.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same journal

Crystal-storing histiocytosis causing severe acute kidney injury.

Kidney international·2026
Same journal

Peritoneal dialysis in a patient with extensive burn scarring.

Kidney international·2026
See all related articles

Area of Science:

  • Nephrology
  • Obstetrics
  • Reproductive Medicine

Background:

  • IgA nephropathy (IgAN) is a common glomerular disease.
  • The impact of pregnancy on IgAN and vice versa requires careful evaluation for optimal patient management.

Purpose of the Study:

  • To assess the effects of IgA nephropathy on pregnancy outcomes.
  • To evaluate the influence of pregnancy on the natural history of IgA nephropathy.

Main Methods:

  • Retrospective analysis of 118 women with IgAN who had 168 pregnancies between 1970-1988.
  • Assessment of pregnancy outcomes including spontaneous abortion, normal delivery, live birth, and perinatal death.
  • Longitudinal follow-up of 85 women to evaluate changes in renal function (GFR), blood pressure, and proteinuria.

Related Experiment Videos

Main Results:

  • Overall perinatal mortality was 4%, but significantly higher in women with pre-conception GFR < 70 ml/min (14%) or hypertension > 140/90 mm Hg (33%).
  • Adverse outcomes were more frequent in the 1970s compared to the 1980s, with perinatal death rates of 9% and 0%, respectively.
  • Long-term follow-up showed modest declines in GFR (19%), increases in blood pressure (11%), and proteinuria (7%) in a subset of women. Five cases showed accelerated renal function decline potentially linked to gestation.

Conclusions:

  • Most women with IgA nephropathy can expect successful pregnancies if they are normotensive and have a pre-conception GFR > 70 ml/min.
  • Pregnancy generally has a limited impact on the long-term course of IgA nephropathy under optimal conditions.
  • Improved obstetric and nephrologic care significantly reduced adverse pregnancy outcomes in IgAN patients over time.