Related Experiment Video
Updated: Jul 13, 2026

Synthesis of High Purity Nonsymmetric Dialkylphosphinic Acid Extractants
Published on: October 19, 2017
Improved analysis of dialkylphosphates in urine using strong anion exchange disk extraction and in-vial
Wei-Chao Lin1, Chang-Yuan Hsieh, Ho-Yuan Chang
1Department of Cosmetics Sciences, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan, Republic of China.
Abstract:
Determination of dialkylphosphates (DAPs) in urine is useful for assessing human exposure to organophosphates (OPs). An improved method for the determination of four DAPs based on a strong anion exchange (SAX) disk extraction and in-vial derivatization was presented in this study. The matrix effect of urine components such as chloride ion and phosphate ion by using a SAX disk to extract DAPs in urine analysis was carefully evaluated. It was observed that the chloride ion mainly affected the extraction of diethylphosphate (DEP), dimethylthiophosphate (DMTP), and diethylthiophosphate (DETP) in urine. The addition of silver hydroxide could significantly improve the extraction efficiencies of these three DAPs, but it decreases the extraction efficiencies of dimethyldithiophosphate (DMDTP) and diethyldithiophosphate (DEDTP). The LOD of this method for DMTP, DETP, DMDTP, and DEDTP are 5, 5, 11, and 5 microg/L, respectively. A pretreatment strategy for the determination of DMTP, DMDTP, DETP, and DEDTP in urine was proposed which can provide reliable and prompt determination of routine urine analysis.
More Related Videos
Related Concept Videos
Ion-Exchange Chromatography
Dialysis
Qualitative Analysis
For instance, group IV...
Analyte Adsorption and Distribution
Ion Exchange

