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Updated: Jul 13, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
Published on: December 23, 2022
EcoProDB: the Escherichia coli protein database.
Hongseok Yun1, Jeong Wook Lee, Joonwoo Jeong
1Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Daejeon 305-701, Korea.
EcoProDB is a novel database for comparative proteomics in Escherichia coli. It integrates 2D gel data, expression levels, and localization, enabling new research hypotheses.
Area of Science:
- Proteomics
- Bioinformatics
- Systems Biology
Background:
- Comparative proteomics of Escherichia coli (E. coli) is crucial for understanding cellular functions.
- Existing databases lack integrated 2D gel proteomics data with expression and localization information.
Purpose of the Study:
- To develop EcoProDB, a comprehensive web-based database for comparative proteomics of E. coli.
- To provide an interactive platform for analyzing E. coli protein expression under various conditions.
Main Methods:
- Data integration from diverse databases and literature.
- Development of a web interface with a Map Browser for visualization.
- Implementation of tools for uploading and analyzing user-submitted 2D gel data.
Main Results:
- EcoProDB houses extensive information on E. coli proteins identified via 2D gels.
- The database offers comparative data on subcellular localization and theoretical/experimental 2D maps.
- Expression levels of E. coli proteins across different conditions are accessible.
Conclusions:
- EcoProDB serves as a valuable resource for comparative E. coli proteomics research.
- The integrated platform facilitates hypothesis generation and knowledge discovery.
- Researchers can leverage EcoProDB to explore E. coli protein expression and function.
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