Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...

Drug Dosing: Infants and Children

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Linking public health nursing competencies and service-learning in a global setting.

Public health nursing (Boston, Mass.)·2017

Same author

The effects of neurodynamic mobilization on fluid dispersion within the tibial nerve at the ankle: an unembalmed cadaveric study.

The Journal of manual & manipulative therapy·2012

Same author

Serum caffeine concentrations in preterm neonates.

American journal of perinatology·2006

Same author

Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes.

Bioorganic & medicinal chemistry·2005

Same author

Varicella zoster as a manifestation of immune restoration disease in HIV-infected children.

The Journal of allergy and clinical immunology·2004

Same author

Maternal smoking and partial exchange transfusion for neonatal polycythemia.

American journal of perinatology·2002

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Error reduction when prescribing neonatal parenteral nutrition.

Cynthia L Brown¹, Nancy A Garrison, Alastair A Hutchison

¹Department of Pharmacy, University at Buffalo, State University of New York, The Women and Children's Hospital of Buffalo, Kaleida Health, Buffalo, New York 14222-2006, USA.

American Journal of Perinatology

|July 13, 2007

Summary

Implementing an interactive computerized parenteral nutrition (PN) worksheet significantly reduced PN prescribing errors in a neonatal intensive care unit. This tool improved accuracy for all PN orders and especially for peripheral PN, benefiting patient safety.

Related Experiment Videos

Last Updated: Jul 13, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Area of Science:

Neonatal intensive care
Pediatric pharmacology
Patient safety

Background:

Parenteral nutrition (PN) prescribing errors are a significant concern in neonatal intensive care units (NICUs).
Previous audits identified high PN prescribing error rates, with pediatric residents making more errors than neonatal nurse practitioners (NNPs).

Purpose of the Study:

To reduce the PN prescribing error rate by implementing an improved ordering process.
To evaluate the impact of an interactive computerized PN worksheet on prescribing accuracy.

Main Methods:

A retrospective cross-sectional study analyzed 480 parenteral nutrition (PN) orders.
An interactive computerized PN worksheet was voluntarily implemented.
A time management study was conducted to identify system improvements.

Main Results:

The overall PN prescribing error rate decreased from 27.9% to 11.7%.
Use of the interactive computerized PN worksheet reduced the error rate from 14.5% to 6.8% for all PN orders and from 29.3% to 9.6% for peripheral PN orders.
No significant difference in error rates was observed between pediatric residents and NNPs after implementation.

Conclusions:

An interactive computerized PN worksheet is effective in reducing parenteral nutrition (PN) prescribing errors.
The tool is particularly beneficial for peripheral PN orders.
System improvements in PN ordering, informed by time management studies, further enhance accuracy.