Related Experiment Video

Updated: Jul 13, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

[Role of IgE-dependent reactions in atopic dermatitis]

Jarosław Dynowski1, Krystyna Wasowska-Królikowska, Małgorzata Modzelewska-Hołyńska

  • 1Klinika Alergologii, Gastroenterologii i Zywienia Dzieci III Katedry Pediatrii UM, ul. Sporna 36/50, 91-738 Łodz, Poland.

Medycyna Wieku Rozwojowego
|July 13, 2007
PubMed

Insights

Common allergens like animal hair and food cause atopic dermatitis in children. While specific IgE tests are useful, they may not be sufficient for a complete diagnosis of this complex skin condition.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Immunology

Context:

  • Atopic dermatitis is a prevalent chronic inflammatory skin condition in children.
  • Its pathogenesis is multifactorial, involving genetic and environmental factors.
  • Identifying causative allergens is crucial for effective management.

Purpose:

  • To determine the most frequent allergens implicated in childhood atopic dermatitis.
  • To evaluate the diagnostic utility of specific IgE testing in this population.

Summary:

  • The study analyzed 36 children with atopic dermatitis, collecting clinical histories and performing IgE testing.
  • Eosinophilia, elevated total IgE, and specific IgE (sIgE) were observed in a subset of patients.
  • Animal hair and food allergens were the most commonly identified triggers, though a significant number of patients had negative sIgE results despite clinical symptoms.

Impact:

  • Highlights the importance of considering animal hair and food allergens in pediatric atopic dermatitis.
  • Suggests that specific IgE testing alone may be insufficient for diagnosing all cases.
  • Informs clinical practice regarding comprehensive allergy assessment in children with atopic dermatitis.
Abstract

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...