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Blood pressure and kidney size in term newborns with intrauterine growth restriction

Oscar Tadashi Matsuoka1, Simone Shibao, Cléa Rodrigues Leone

  • 1Neonadal and Clinical Pediatrics Division, Children's Institute, Nursery Annex of the Maternity of the Clinics Hospital of the São Paulo, University Medical School, São Paulo, Brazil. oscar_tadashi@yahoo.com.br

Sao Paulo Medical Journal = Revista Paulista De Medicina
|July 13, 2007
PubMed

Insights

Intrauterine growth restriction (IUGR) did not significantly affect newborn systolic blood pressure (SBP) or kidney development in the first month. This suggests IUGR may not influence early SBP trajectories in term infants.

Area of Science:

  • Neonatal Physiology
  • Pediatric Cardiology
  • Developmental Biology

Background:

  • Low birth weight is linked to elevated blood pressure later in life.
  • Intrauterine growth restriction (IUGR) is a significant concern in perinatal medicine.

Purpose of the Study:

  • To determine the impact of IUGR on newborn systolic blood pressure (SBP).
  • To assess the relationship between IUGR and kidney development markers in neonates.

Main Methods:

  • A prospective comparative study involving 35 newborns with IUGR and 35 controls.
  • Analysis included birth weight, kidney weight ratios, plasma renin activity (PRA), and SBP monitoring over the first month.
  • Exclusion criteria included malformations and low Apgar scores.

Main Results:

  • No significant differences in SBP evolution, kidney weight/birth weight ratio, or PRA between IUGR and control groups.
  • Positive correlations were observed between SBP and birth weight/BMI in IUGR infants on day 7, and with birth weight/length on day 30.
  • An inverse correlation between SBP and kidney weight/birth weight ratio was noted on day 7 but not sustained.

Conclusions:

  • IUGR does not appear to influence SBP, PRA, or kidney weight in term newborns during the first month of life.
  • Early SBP in term infants may be influenced by factors other than IUGR, despite correlations with anthropometric measures.
Abstract

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