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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
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Published on: May 7, 2019

Structural adaptations in compressed articular cartilage measured by diffusion tensor imaging.

S K de Visser1, R W Crawford, J M Pope

  • 1School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.

Osteoarthritis and Cartilage
|July 13, 2007
PubMed
Summary

Diffusion tensor imaging reveals how collagen fibers in articular cartilage adapt to mechanical compression. This technique shows potential for non-invasively assessing cartilage health and diagnosing osteoarthritis.

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Area of Science:

  • Biomedical Engineering
  • Magnetic Resonance Imaging
  • Tissue Mechanics

Background:

  • Articular cartilage is a complex tissue crucial for joint function.
  • Understanding collagen fiber adaptations to mechanical stress is vital for cartilage health.
  • Current methods for evaluating cartilage structure and function are limited.

Purpose of the Study:

  • To demonstrate diffusion tensor magnetic resonance micro-imaging (DT-MRI) for observing collagen fiber adaptations.
  • To correlate mechanical compression with changes in collagen fiber orientation in articular cartilage.

Main Methods:

  • Acquired spin-echo and diffusion tensor images of bovine cartilage at 7.0T.
  • Image analysis included T2, diffusivity parameters, and eigenvector orientations.
  • Cartilage samples were imaged in relaxed and compressed states.

Main Results:

  • Found a correlation between compressive strain and changes in diffusivity magnitude and direction.
  • Compression decreased eigenvalues, especially in surface and transitional zones.
  • Collagen fiber bundles oriented more parallel to the surface upon compression, with significant eigenvector changes in the transitional region.

Conclusions:

  • Diffusion tensor imaging effectively monitors collagen fiber directional changes under compression.
  • DT-MRI offers a potential non-invasive method for functional cartilage evaluation.
  • This technique may aid in diagnosing and treating osteoarthritis.