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CK levels in unmedicated bipolar patients.
Michael Segal1, Avi Avital, Marina Drobot
1Flügelman's (Mazra) Mental Health Medical Center, Acre, Israel. Segal@mazra.health.gov.il
Summary
Serum creatine kinase (CK) levels are higher in manic bipolar disorder patients compared to depressed patients. This finding suggests CK levels may reflect cognitive differences, not motor activity, between manic and depressive states.
Area of Science:
- Neuroscience
- Psychiatry
- Biochemistry
Background:
- Increased serum creatine kinase (CK) activity has been reported in patients with schizophrenia and affective psychoses.
- Bipolar disorder is characterized by distinct manic and depressive states, often with differing clinical presentations.
Purpose of the Study:
- To investigate and compare serum creatine kinase (CK) levels in unmedicated bipolar inpatients during manic versus depressive states.
- To explore the relationship between CK levels and clinical symptoms in bipolar disorder.
Main Methods:
- Serum CK levels were measured in 52 unmedicated bipolar inpatients.
- 17 patients were assessed in both manic and depressive states.
- Clinical assessments used the Hamilton Rating Scale for Depression and Young Mania Rating Scale.
Main Results:
- Manic patients exhibited significantly higher serum CK levels compared to depressed patients.
- Within the same patients, CK levels were higher during the manic phase than the depressive phase.
- No correlation was found between CK levels and motor symptoms, suggesting a link to cognitive function.
Conclusions:
- Contrasting serum CK levels support the distinct neurobiological underpinnings of manic and depressive states in bipolar disorder.
- Serum CK levels in bipolar disorder may be indicative of "thinking speed" rather than motor activity.
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