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Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

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Multifocal calcifying epithelial odontogenic tumor.

Parish P Sedghizadeh¹, Derek Wong, Charles F Shuler

¹Division of Diagnostic Sciences, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA 90089-0641, USA.sedghiza@usc.edu

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

|July 17, 2007

Summary

This study reports a rare multifocal calcifying epithelial odontogenic tumor (CEOT), also known as Pindborg tumor, affecting multiple jaw sites. This unique presentation challenges previous understanding of CEOT as typically unifocal.

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Area of Science:

Oral Pathology
Odontogenic Neoplasms
Oncology

Background:

Calcifying epithelial odontogenic tumor (CEOT), or Pindborg tumor, is a rare, benign odontogenic neoplasm.
CEOT commonly presents as a unifocal lesion in the jaw, appearing as swelling clinically and a mixed radiolucent-radiopaque mass radiographically.
Multifocal odontogenic lesions are atypical and often associated with genetic syndromes like nevoid basal cell carcinoma syndrome.

Observation:

A unique case of a 51-year-old male with multifocal CEOT affecting both the maxilla and mandible is presented.
Histopathologic examination of biopsy samples from all affected sites confirmed features consistent with CEOT.
The multifocal presentation in this case is an unusual phenomenon, as CEOT is typically unifocal and has not been previously reported as multifocal.

Findings:

The study documents the first reported case of multifocal calcifying epithelial odontogenic tumor.
Histopathology confirmed CEOT in multiple distinct sites within the same patient's jawbones.
This finding suggests the potential existence of a previously unrecognized multifocal variant of CEOT.

Implications:

This case expands the known clinical spectrum of calcifying epithelial odontogenic tumors.
The recognition of a multifocal variant may necessitate revised diagnostic and treatment approaches for CEOT.
Further research is warranted to investigate the potential genetic or etiological factors underlying multifocal CEOT.