Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir
Nicola Gianotti1, Monica Guffanti, Laura Galli
1Divisione di Malattie Infettive, Istituto Scientifico San Raffaele, Milan, Italy.
Abstract:
The QRS interval of 56 out of 75 (74.7%) HIV-infected, drug-experienced patients (66.7% men) increased during treatment with boosted or unboosted atazanavir by a median 5 ms (interquartile range 0-9; P < 0.0001); the PR and the QTc intervals did not change significantly. New asymptomatic bundle branch blocks were observed in four patients; one subject with a baseline first-degree atrioventricular block developed symptomatic bradyarrhythmia while receiving atenolol. The electrocardiographic monitoring of patients treated with atazanavir seems advisable.
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