Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Germ cells: the eternal link between generations.

M Azim Surani1

  • 1Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. a.surani@gurdon.cam.ac.uk

Comptes Rendus Biologies
|July 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NELFA supports naïve pluripotency and drives 8C-like state in human embryonic stem cells.

Nature communications·2026
Same author

A post-implantation model of human embryo development includes a definitive hematopoietic niche.

Cell reports·2025
Same author

The emergence of human primordial germ cell-like cells in stem cell-derived gastruloids.

Science advances·2025
Same author

Stem cell-based embryo models: a tool to study early human development.

Science China. Life sciences·2025
Same author

The role of KLF4 in human primordial germ cell development.

Open biology·2025
Same author

Temporal and regional X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing.

Nature structural & molecular biology·2025
Same journal

Integrating intraspecific trait variation and spatiotemporal variability of selection as levers of action in forest management.

Comptes rendus biologies·2026
Same journal

[Managing mixed forest stands : bridging the gap between silviculture and ecological theory].

Comptes rendus biologies·2026
Same journal

[Which forests for which biodiversity under climate change?]

Comptes rendus biologies·2026
Same journal

[Impacts of climate change on the functioning and productivity of agroecosystems: a focus on the impact of interactions between CO<sub>2</sub>, temperature and water deficit].

Comptes rendus biologies·2026
Same journal

Autogenic transitions in individuality.

Comptes rendus biologies·2026
Same journal

Assessing the potential effects of climate change on future forest composition in France.

Comptes rendus biologies·2026
See all related articles

Blimp1 is essential for primordial germ cell (PGC) development by repressing the somatic cell program. This transcriptional repressor ensures the correct specification of germ cells from early embryonic epiblast cells.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Pluripotent epiblast cells give rise to both somatic and germ cells.
  • Germ cell lineage specification involves suppressing the somatic cell program.

Purpose of the Study:

  • To investigate the role of Blimp1 in primordial germ cell (PGC) specification.
  • To understand how Blimp1 represses the somatic program during germ cell development.

Main Methods:

  • Analysis of gene expression patterns in early embryos.
  • Functional studies on the transcriptional repressor Blimp1.
  • Investigating the role of SET/PR domain proteins in cell fate decisions.

Main Results:

  • Blimp1, a transcriptional repressor, is crucial for PGC specification.

Related Experiment Videos

  • Blimp1 actively suppresses the somatic cell program in developing germ cells.
  • Evidence supports Blimp1's role in germline establishment.

    • Conclusions:

    • Blimp1 is a key regulator in the specification of primordial germ cells.
    • Repression of the somatic program by Blimp1 is vital for germ cell lineage formation.