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Updated: Jul 13, 2026

Surgical Labyrinthectomy of the Rat to Study the Vestibular System
Published on: May 19, 2018
[Otogenic (labyrinthine) vertigo--when the ear fails to keep us in equilibrium]
Eike Krause1, Robert Gürkov, John Martin Hempel
1Klinik für Hals-Nasen-Ohrenheilkunde der Ludwig-Maximilians-Universität München, Klinikum Grosshadern und Innenstadt. Eike.Krause@med.uni-muenchen.de
Abstract:
The peripheral vestibular organ within the bony labyrinth of the inner ear is closely connected to the other parts of the equilibrium system. As a result of its constant active interaction with the other elements, it plays a major role in ensuring that we can maintain our balance. In the event of a disorder, otogenic vertigo can occur. Important evidence of a peripheral-vestibular disturbance is provided by the patient's history of dizziness, and confirmation of the suspected diagnosis is achieved by clinical and other appropriate examinations and tests. Common differential diagnoses include benign paroxysmal positional vertigo, Ménière's disease, and vestibular neuropathy. These can be readily differentiated by applying a systematic approach, and usually respond to treatment. In recent years, improved diagnostic tools have made it possible to test the functioning of the otolith organs, and this may lead to new therapeutic options in labyrinthine vertigo in the future.
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