Related Experiment Video
Updated: Jul 13, 2026

Dendritic Spine Quantification Using an Automatic Three-Dimensional Neuron Reconstruction Software
Published on: September 27, 2024
[Spine biology in psychiatric diseases]
1Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, 565 0874 Japan. takumi@obi.or.jp
Abstract:
Local translation near or in spines is thought to be a molecular basis of synaptic plasticity and its abnormalities may cause psychiatric diseases. The RNA binding protein, TLS, which is identified from a screening by using a pharmacological model for schizophrenia, is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. TLS facilitates transport of mRNA encoding an actin-stabilizing protein, Nd1-L, to dendritic spines. Moreover, myosin-Va is essential for the accumulation of TLS and its target RNA, Nd1-L, in dendritic spines.
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