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Related Experiment Videos

Beta-tricalcium phosphate release from brushite cement surface.

M Hamdan Alkhraisat1, F Tamimi Mariño, J Rubio Retama

  • 1Departamento de Estomatología III, Facultad de Odontología, UCM, Plaza Ramón y Cajal S/N, 28040 Madrid, Spain.

Journal of Biomedical Materials Research. Part A
|July 20, 2007
PubMed
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Brushite cements

Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Calcium Phosphate Cements

Background:

  • Brushite cements exhibit promising biocompatibility, bioresorbability, and osteoconductivity for bone regeneration.
  • The surface disintegration of brushite cements, particularly in vascularized environments, requires further investigation for clinical safety.

Purpose of the Study:

  • To investigate the factors influencing the surface disintegration of brushite cements.
  • To evaluate the impact of carboxylic acids and viscosity-enhancing polysaccharides on cement stability.

Main Methods:

  • Brushite cements were prepared using phosphoric, glycolic, tartaric, and citric acids, with and without chondroitin-4 sulfate and hyaluronic acid.
  • Cement samples were immersed in distilled water, and analyses included weight loss, microstructure, liquid viscosity, particle size, and zeta potential.

Related Experiment Videos

  • Techniques employed were X-ray diffraction, FTIR spectroscopy, light scattering, scanning electron microscopy, and optical microscopy.

    • Main Results:

    • Released particles were identified as beta-tricalcium phosphate (β-TCP), with amounts varying based on the carboxylic acid used.
    • Hyaluronic acid and chondroitin-4 sulfate reduced particle release from citric acid-modified cements.
    • Increased viscosity of the citric acid solution with hyaluronic acid led to reduced particle release.

    Conclusions:

    • The water solubility of calcium carboxylate and the viscosity of the mixing liquid are key factors governing brushite cement surface disintegration.
    • Modification with specific carboxylic acids and polysaccharides can enhance cement stability for clinical applications.