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Updated: Jul 13, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Visual function in infants with non-syndromic craniosynostosis
D Ricci1, G Vasco, G Baranello
1Pediatric Neurology Unit, Catholic University, Rome, Italy.
Insights
Children with single-suture craniosynostosis often have visual impairments. Abnormalities in eye movements and visual fields are common, varying by craniosynostosis type.
Area of Science:
- Pediatric Ophthalmology
- Neuroscience
- Craniofacial Surgery
Background:
- Single-suture non-syndromic craniosynostosis affects skull development in infants.
- Potential impacts on visual function are not fully understood.
- Early visual assessment is crucial for timely intervention.
Purpose of the Study:
- To evaluate visual function in infants with single-suture non-syndromic craniosynostosis.
- To identify specific visual abnormalities associated with different types of craniosynostosis.
- To determine the relationship between craniosynostosis type and visual impairment severity.
Main Methods:
- Assessed 38 infants (3.5-13 months) with plagiocephaly, trigonocephaly, or scaphocephaly.
- Utilized a specialized battery of tests for infant visual function.
- Analyzed data on eye movements, visual fields, and fixation shifts.
Main Results:
- 32 out of 38 infants (84%) exhibited at least one visual abnormality.
- Abnormal eye movements were noted in 8 infants, predominantly those with plagiocephaly (6/11).
- Visual field abnormalities were frequent in plagiocephaly (5/11); fixation shifts were more common in scaphocephaly.
Conclusions:
- Visual impairment in infants is linked to the specific type of single-suture craniosynostosis.
- Different craniosynostosis types correlate with distinct visual function deficits.
- Further research is needed to assess the impact of surgical correction on visual outcomes.
Abstract:
The aim of this study was to assess various aspects of visual function in children with single-suture, non-syndromic craniosynostosis. Thirty-eight infants (28 males, 10 females; age range 3.5-13mo, mean age 7mo, 11 with plagiocephaly, 12 with trigonocephaly, and 15 with scaphocephaly), were assessed with a battery of tests specifically designed to assess various aspects of visual function in infancy. Thirty-two of the 38 infants had at least one abnormality on one of the aspects of visual function assessed. Abnormal eye movements were found in eight infants of the whole cohort and were mainly found in infants with plagiocephaly (6/11), who also had frequent visual field abnormalities (5/11). In contrast, fixation shift, an aspect of visual function related to the integrity of parietal lobes, was more frequently abnormal in patients with scaphocephaly. Our results suggest that the presence and severity of visual impairment is related to the type of craniosynostosis. Follow-up studies after surgical correction are needed to evaluate the possible beneficial effects of reconstructive surgery on visual function.
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