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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes...
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Videos

Macrogol 3350 plus electrolytes for chronic constipation in children: a single-centre, open-label study.

Winita Hardikar1, Noel Cranswick, Ralf G Heine

  • 1Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville, Victoria, Australia. winita.hardikar@rch.org.au

Journal of Paediatrics and Child Health
|July 20, 2007
PubMed
Summary

Macrogol 3350 plus electrolytes effectively treats chronic constipation in children aged 2-11 years, improving bowel movements and reducing abdominal pain. The treatment demonstrated a favorable safety profile with good tolerability in this pediatric population.

Related Experiment Videos

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacological Interventions
  • Digestive Health

Background:

  • Chronic constipation is a common condition in children.
  • Macrogol 3350-based laxatives are established for adult constipation.
  • Pediatric safety and efficacy data for Macrogol 3350 were previously limited.

Purpose of the Study:

  • To evaluate the safety and efficacy of Macrogol 3350 plus electrolytes.
  • To assess treatment outcomes in children aged 2-11 years with chronic constipation.
  • To determine the impact on bowel movement frequency and associated symptoms.

Main Methods:

  • An open-label, non-randomized study involving 78 children (2-11 years) with chronic constipation.
  • Treatment with Macrogol 3350 plus electrolytes for 12 weeks.
  • Assessment of spontaneous defaecations, stool form, abdominal pain, and other efficacy variables.

Main Results:

  • Significant increase in spontaneous defaecations per week (P < 0.001).
  • Marked reduction in abdominal pain (P < 0.0001) and pain during defaecation (P < 0.0001).
  • Treatment was well-tolerated, with most adverse events mild and unrelated to treatment.

Conclusions:

  • Macrogol 3350 plus electrolytes is a safe and effective treatment for pediatric chronic constipation.
  • The preparation shows significant improvements in efficacy variables and symptom resolution.
  • High tolerability supports its use in children aged 2-11 years.