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Updated: Jul 13, 2026
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
WITHDRAWN: Human chorionic gonadotrophin for recurrent miscarriage.
The Cochrane Database of Systematic Reviews
|July 20, 2007
Summary
Human chorionic gonadotrophin may reduce miscarriage risk in women with recurrent miscarriages. However, more research is needed due to limited and variable quality evidence from trials.
Area of Science:
- Reproductive Endocrinology
- Maternal-Fetal Medicine
- Clinical Trial Analysis
Background:
- Recurrent miscarriage may be linked to abnormal follicular phase hormone function.
- Human chorionic gonadotrophin (hCG) is investigated for its potential role in preventing pregnancy loss.
Purpose of the Study:
- To evaluate the impact of human chorionic gonadotrophin (hCG) administration in early pregnancy on miscarriage risk.
- Focus on women with a history of recurrent miscarriage.
Main Methods:
- Systematic review of randomized controlled trials sourced from the Cochrane Pregnancy and Childbirth Group trials register.
- Inclusion criteria: trials comparing hCG with placebo or no treatment in women with two or more miscarriages.
- Eligibility and quality assessment performed by a single reviewer.
Main Results:
- Four trials with 180 women were included, exhibiting variable methodological quality.
- A statistically significant reduction in miscarriage risk was observed with hCG use (OR 0.26, 95% CI 0.14-0.52).
- The observed effect is potentially influenced by two weaker studies, necessitating cautious interpretation.
Conclusions:
- Current evidence is insufficient to definitively assess the efficacy of human chorionic gonadotrophin for preventing miscarriage in women with unexplained recurrent spontaneous miscarriage.
- Further high-quality research is required to establish the role of hCG in managing recurrent pregnancy loss.
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