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Related Concept Videos

Mass Spectrum: Interpretation01:24

Mass Spectrum: Interpretation

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An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...
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Mass Spectrometers01:16

Mass Spectrometers

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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
7.4K
Mass Spectrometry: Overview01:19

Mass Spectrometry: Overview

9.9K
Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...
9.9K
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

2.0K
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
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Updated: Mar 22, 2026

Dithranol as a Matrix for Matrix Assisted Laser Desorption/Ionization Imaging on a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
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Fourier transform mass spectrometry-advancing years (1992-mid. 1996).

T Dienes1, S J Pastor1, S Schürch1

  • 1Department of Chemistry, University of California-Riverside, Riverside, California 92521.

Mass Spectrometry Reviews
|April 16, 2016
PubMed
Summary
This summary is machine-generated.

This review covers recent advancements in Fourier transform mass spectrometry (FTMS), including theory, instrumentation, ionization techniques like electrospray ionization (ESI) and MALDI, and applications in diverse fields.

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Fourier transform mass spectrometry (FTMS) is a powerful analytical technique.
  • Regular reviews are published to track its progress.

Purpose of the Study:

  • To provide a comprehensive overview of recent developments in FTMS.
  • To serve as a starting point for new researchers and a literature cross-section for experts.

Main Methods:

  • Review of theoretical and instrumental advancements in FTMS.
  • Discussion of electrospray ionization (ESI) and MALDI techniques.
  • Exploration of ion dissociation techniques for structural insights.

Main Results:

  • Highlights emerging applications in surface analysis, polymer analysis, and Buckminsterfullerenes.
  • Covers hydrogen/deuterium exchange studies.
  • Presents a broad overview of the current FTMS landscape.

Conclusions:

  • FTMS continues to evolve with significant theoretical and instrumental progress.
  • The technique offers versatile applications across various scientific domains.
  • This review serves as a valuable resource for understanding the state-of-the-art in FTMS.