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A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Antipsychotic medications for cocaine dependence
1ASL RM/E, Deparment of Epidemiology, Via di Santa Costanza 53, Rome, Lazio, Italy, 00198. amato@asplazio.it
The Cochrane Database of Systematic Reviews
|July 20, 2007
Summary
Antipsychotic medications are not currently supported for cocaine dependence treatment. While risperidone may reduce dropouts, more research is needed on efficacy and side effects for this addiction.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Cocaine dependence is a significant public health issue with high relapse rates and numerous medical/psychosocial complications.
- Currently, no proven pharmacological treatments exist for cocaine dependence, despite advances in addiction neurobiology.
- The development of effective medications is crucial for managing this disorder.
Purpose of the Study:
- To evaluate the efficacy and acceptability of antipsychotic medications for treating cocaine dependence.
- To synthesize evidence from randomized controlled trials (RCTs) and controlled clinical trials (CCTs).
Main Methods:
- Comprehensive literature search of multiple databases (MEDLINE, EMBASE, CINAHL, Cochrane) up to October 2006.
- Inclusion of all RCTs and CCTs investigating antipsychotic use for cocaine dependence, including non-English literature.
- Independent data extraction and quality assessment by two authors.
Main Results:
- Seven small studies (293 participants) examined risperidone, olanzapine, and haloperidol.
- No significant differences in efficacy were found between antipsychotics and placebo for primary outcomes.
- Risperidone showed a trend towards reducing dropouts (RR 0.77), but data on side effects, cocaine use, and craving were limited.
Conclusions:
- Current evidence from small clinical trials does not support the use of antipsychotic medications for cocaine dependence.
- Larger, well-designed RCTs are needed to investigate efficacy, side effects, and other relevant outcomes.
- Further research should also explore other medication classes, such as anticonvulsants, for cocaine dependence treatment.
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