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Total synthesis of luotonin A and 14-substituted analogues
1Unit for Organic Chemistry, Department of Biosciences and Nutrition, Karolinska Institute, SE-14157 Huddinge, Sweden.
Abstract:
A new and concise synthesis of luotonin A was achieved from the previously described compounds ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate and 1-(2-nitrophenyl)prop-2-en-1-one. New 14-substituted luotonin A analogues were prepared using 14-chloroluotonin A as the key intermediate.
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