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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Flexural Stress01:16

Flexural Stress

When analyzing bending in symmetric members, it's crucial to understand how stresses distribute when subjected to bending moments. This stress distribution is effectively described by applying fundamental mechanics and material science principles, particularly Hooke's Law for elastic materials.
Hooke's Law states that within the material's elastic limits, stress is directly proportional to strain. In a member experiencing a bending moment, the strain at any point is relative to its distance...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Related Experiment Video

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A Rat Model of Compound Acne
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Published on: November 1, 2024

Childhood flexural comedones: a new entity.

Margarita Larralde1, María Eugenia Abad, Andrea Santos Muñoz

  • 1Department of Dermatology, Alemán Hospital, Buenos Aires, Argentina. margaritalarralde@fibertel.com.ar

Archives of Dermatology
|July 20, 2007
PubMed
Summary

Flexural comedones, a newly described skin condition in children, present with unique double-orifice lesions, primarily in the axilla. Further research is needed to understand this pediatric skin disorder.

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Area of Science:

  • Dermatology
  • Pediatric Medicine

Background:

  • Comedones are common in acne, typically affecting seborrheic skin areas.
  • Disseminated comedones can indicate other dermatological conditions.
  • Flexural comedones, characterized by double orifices and epidermal connection, were not previously described as a distinct entity.

Purpose of the Study:

  • To characterize a newly observed disorder: flexural comedones.
  • To document the clinical presentation and demographics of patients with flexural comedones.

Main Methods:

  • A cross-sectional descriptive study was conducted between April 2004 and July 2006.
  • Included 40 pediatric and adolescent patients diagnosed with flexural comedones.
  • Data collection involved clinical observation and skin biopsies in select cases.

Main Results:

  • The study included 40 patients (52% female, 48% male) with a mean age of 6.2 years.
  • Lesions were predominantly unilateral (80%) and located in the axilla (88%).
  • Biopsies were performed on 6 patients to further analyze the condition.

Conclusions:

  • Flexural comedones represent a previously undescribed dermatological entity.
  • The disorder, named childhood flexural comedones, is characterized by its clinical appearance, location, and age group.
  • Further investigation and follow-up studies are recommended for a larger patient cohort.