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Updated: Jul 13, 2026
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Yttrium 90 microsphere selective internal radiation treatment of hepatic colorectal metastases
1Department of Surgery, Center for Cancer Care at Goshen Health System, Goshen, IN 46526, USA. sgulec@goshenhealth.com
Objective:
To discuss the basic concepts involved in the development of yttrium 90 (Y-90) microsphere selective internal radiation treatment and review the clinical data pertaining to its application in hepatic colorectal cancer metastases.
Data Sources:
Published studies and scientific paper presentations.
Study Selection:
Randomized clinical studies and retrospective reviews.
Conclusions:
Selective internal radiation treatment is a promising new modality in the treatment of patients with hepatic colorectal cancer metastases as part of a multimodality approach. A chemo-selective internal radiation treatment neoadjuvant approach has a potential to improve therapeutic outcomes. Clinical studies in neoadjuvant and salvage settings are needed for more concrete outcome data and design of optimal multimodality treatment strategies.
