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Updated: Jul 13, 2026

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
Published on: August 12, 2025
Mevastatin increases eNO synthase expression and inhibits lipid peroxidation in human endothelial cells
Casper G Schalkwijk1, Bastiaan van Dam, Coen D A Stehouwer
1Department of Clinical Chemistry, Institute for Cardiovascular Research, Vrije Univeristeit Medical Center, Amsterdam, The Netherlands. C.Schalkwijk@intmed.unimass.nl
Abstract:
Statins can protect endothelial activation independent from their lipid-lowering effects. To gain more insight in mechanisms via which HMG-CoA inhibition may attenuate endothelial activation, we assessed the effects of mevastatin on eNOS expression of non- and modified-LDL treated endothelial cells and on basal and hydrogen peroxide-induced lipid peroxidation. Oxidized-LDL (Ox-LDL), but not glycated or acylated LDL decreased eNOS expression in human endothelial cells. The extent to which Ox-LDL decreases eNOS expression depends on the extent of modification of Ox-LDL. Mevastatin increased eNOS-expression, both in the presence and absence of Ox-LDL. In addition, mevastatin decreased the H(2)O(2)-induced (100 microM) lipid peroxidation in endothelial cells. This study shows that mevastatin has protective effects on endothelial cells by inducing eNOS and by inhibiting lipid peroxidation.
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