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Micronized diosmin (Detralex) for vein-related trophic ulcers: European experience
V S Savel'ev1, A V Pokrovskiĭ, S V Sapelkin
1Chair of Faculty Surgery, Department of Continuing Education, Russian State Medical University, Moscow A V Vishnevsky Institute of Surgery, RAMS, Moscow, Russia.
Abstract:
The paper presents a meta-analysis of 5 large European studies (N - 723) on the micronized diosmin administration to patients with venous trophic ulcers (CEAP class VI). With the use of evidence-based approach, it was shown that micronized diosmin has a statistically significant clinical effect on middle-sized trophic ulcers (5 - 10 cm(2)) that persisted for 6 - 12 months. The study concludes that polyvalent venotonics are an appropriate and valuable addition to complex therapy of complicated chronic venous insufficiency.
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