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Related Experiment Video

Updated: Jul 13, 2026

Murine Full-thickness Skin Transplantation

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Meshed split skin graft for extensive vitiligo.

C R Srinivas¹, Reena Rai, P Uday Kumar

¹Department of Dermatology, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore-641 004, India.

Indian Journal of Dermatology, Venereology and Leprology

|July 24, 2007

Summary

This study presents a novel skin grafting technique for extensive vitiligo. Meshed split-skin grafting with phototoxic blister induction effectively repigmented large depigmented areas, offering a viable treatment option.

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Area of Science:

Dermatology
Surgical Innovation

Background:

Vitiligo is a chronic skin condition characterized by depigmentation.
Treating extensive vitiligo poses challenges due to the need for large graft areas.
Current grafting methods may require extensive recipient site preparation.

Purpose of the Study:

To evaluate the efficacy of meshed split-skin grafting combined with phototoxic blister induction for treating generalized vitiligo.
To assess the repigmentation and cosmetic outcome of this procedure in large depigmented areas.

Main Methods:

A 30-year-old female with generalized vitiligo underwent meshed split-skin grafting.
Phototoxic blisters were induced on the recipient site using 8-methoxypsoralen (8-MOP) and UVA light.
Split-skin grafts were harvested, meshed to increase surface area coverage, and applied to the depigmented areas.

Main Results:

Significant repigmentation of the depigmented skin was observed at 5 months post-procedure.
The meshed graft technique allowed for coverage of large recipient areas with limited donor skin.
The phototoxic blister method facilitated easy epidermal separation, reducing preparation time.

Conclusions:

Meshed split-skin grafting with phototoxic blister induction is an effective method for treating extensive vitiligo.
This technique offers a solution for covering large depigmented areas with minimal scarring risk.
The procedure is time-efficient due to simplified recipient site preparation.