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Published on: February 2, 2022
Aspergillosis after renal transplantation
Mohammad Reza Ardalan1, Khalil Ansarin, Esmail Hejazi
1Renal transplantation unit, Imam Hospital, Tabriz Medical University, Iran.
Summary
A kidney transplant recipient developed invasive pulmonary aspergillosis and thrombotic microangiopathy, leading to severe bleeding and a fatal brain fungal mass. Aggressive antifungal treatment was ineffective.
Area of Science:
- Nephrology
- Infectious Diseases
- Pulmonology
Background:
- Renal transplantation is associated with increased risk of opportunistic infections.
- Invasive pulmonary aspergillosis is a severe complication in immunocompromised patients.
Purpose of the Study:
- To report a rare case of invasive pulmonary aspergillosis with thrombotic microangiopathy post-renal transplant.
- To highlight the challenges in managing invasive fungal infections in transplant recipients.
Main Methods:
- Case report of a 32-year-old male renal transplant recipient.
- Clinical presentation, diagnostic workup, and treatment course were documented.
Main Results:
- The patient presented with invasive pulmonary aspergillosis, bronchial ulcerations, massive hemoptysis, and thrombotic microangiopathy.
- Despite antifungal therapy, the patient experienced a fatal brain fungal mass lesion.
Conclusions:
- Invasive pulmonary aspergillosis can present with severe complications like hemoptysis and thrombotic microangiopathy in renal transplant patients.
- Fungal brain mass apoplexy is a rare but devastating outcome in this population.
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