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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Cytomegalovirus Disease

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Related Experiment Video

Updated: Jul 13, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Multicentric reticulohistiocytosis.

A G Rao1, T S Lakshmi, V Vani

  • 1Department of Dermatology, Osmania General Hospital, Afzalgunj, Hyderabad.

Indian Journal of Dermatology, Venereology and Leprology
|July 24, 2007
PubMed
Summary

A 41-year-old man presented with painful nodules and joint issues. Histopathology confirmed multicentric reticulohistiocytosis, a rare condition.

Area of Science:

  • Rheumatology
  • Dermatology
  • Pathology

Background:

  • Multicentric reticulohistiocytosis is a rare, chronic, non-Langerhans cell histiocytosis.
  • It typically presents with characteristic skin and joint manifestations.

Purpose of the Study:

  • To report a case of multicentric reticulohistiocytosis presenting with multiple nodules and arthropathies.
  • To highlight the importance of histopathological confirmation for diagnosis.

Main Methods:

  • Clinical presentation of a 41-year-old male patient with painful nodules and arthropathies.
  • Histopathological examination of nodule biopsies.

Main Results:

  • The patient exhibited multiple, painful, tender nodules on palms, soles, scalp, limbs (predominantly around joints), and ear helices.

Related Experiment Videos

Last Updated: Jul 13, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

  • Associated arthropathies were noted.
  • Histopathological study confirmed multicentric reticulohistiocytosis.

    • Conclusions:

    • Multicentric reticulohistiocytosis can present with a distinct pattern of cutaneous and articular involvement.
    • Histopathological analysis is crucial for definitive diagnosis of this rare disorder.