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Updated: Jul 13, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
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Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Cathepsin L activity controls adipogenesis and glucose tolerance

Min Yang1, Yaou Zhang, Jiehong Pan

  • 1Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature Cell Biology
|July 24, 2007
PubMed
Summary

Cathepsin L (CatL) degrades key proteins involved in fat cell development and glucose regulation. Inhibiting CatL improves adipogenesis, glucose uptake, and metabolic health, suggesting CatL as a therapeutic target for obesity and diabetes.

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