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Related Experiment Videos

Understanding the somitogenesis clock: what's missing?

Olivier Cinquin1

  • 1Howard Hughes Medical Institute and Department of Biochemistry, University of Wisconsin - Madison, 433 Babcock Drive, Madison, WI 53706, USA. cinquin@wisc.edu

Mechanisms of Development
|July 24, 2007
PubMed
Summary
This summary is machine-generated.

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Understanding the somitogenesis clock is crucial for vertebrate embryo segmentation. This review evaluates models of gene regulatory networks, focusing on oscillations and their role in segmentation.

Area of Science:

  • Developmental biology
  • Systems biology
  • Genetics

Background:

  • Vertebrate embryonic segmentation relies on complex genetic networks with dynamic gene expression.
  • While network components are known, their interactions and influence on segmentation are poorly understood.
  • Existing mathematical models for network dynamics are limited and mechanistically debated.

Purpose of the Study:

  • To review outstanding problems in the generation of somitogenesis clock oscillations.
  • To explore how these oscillations regulate embryonic segmentation.
  • To evaluate different proposed models for clock mechanisms and their experimental support.

Main Methods:

  • Literature review and synthesis of existing research on somitogenesis.
  • Critical evaluation of proposed models for clock oscillation generation (e.g., negative vs. positive feedback loops).

Related Experiment Videos

  • Analysis of experimental evidence supporting models involving Notch signaling, Lunatic fringe, Her/Hes genes, and Wnt targets.

    • Main Results:

    • Contrasting models for oscillation generation, including negative feedback loops (Notch/Lunatic fringe) and positive feedback mechanisms.
    • Assessment of experimental support for negative feedback models involving Her/Hes genes or Wnt targets.
    • Highlighting discrepancies between various 'clock and wavefront' models explaining clock-segmentation regulation.

    Conclusions:

    • The precise mechanisms generating somitogenesis clock oscillations remain unresolved.
    • Further experimental investigation is needed to address questions arising from simplified models.
    • A comprehensive understanding of the somitogenesis clock is essential for deciphering embryonic segmentation processes.