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Updated: Jul 13, 2026
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Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
[Assessing sperm DNA damage]
E I Cortés-Gutiérrez1, M I Dávila-Rodríguez, C López-Fernández
1Departamento de Genètica, Centro de Investigación Biomèdica del Noreste, Instituto Mexicano del Seguro Social (IMSS), Monterrey, Nuevo León, México.
Actas Urologicas Espanolas
|July 25, 2007
Summary
Sperm DNA fragmentation impacts male infertility, affecting fertilization and embryo development. This review explores technologies for assessing DNA integrity in andrology labs, aiding clinical application.
Area of Science:
- Reproductive Medicine
- Andrology
- Genetics
Context:
- Male factor infertility affects 50% of couples trying to conceive.
- Sperm DNA integrity is crucial for successful fertilization, beyond traditional semen parameters like motility and morphology.
- Assessing sperm DNA fragmentation is not yet a routine part of standard semen analysis.
Purpose:
- To review and update technologies for studying sperm DNA fragmentation.
- To evaluate technological complexity and applicability in andrology laboratories.
- To discuss the implications of high sperm DNA fragmentation on fertility, fertilization, and embryo development.
Summary:
- This review focuses on technologies for assessing sperm DNA fragmentation, a critical factor in male infertility.
- It evaluates the practical use of these technologies in andrology labs based on available resources.
- The review also examines the consequences of elevated sperm DNA fragmentation on reproductive outcomes.
Impact:
- Provides a guide for selecting appropriate sperm DNA fragmentation testing methods for clinical use.
- Highlights the importance of sperm DNA integrity in male fertility assessment.
- Informs understanding of how DNA fragmentation affects fertilization, embryo quality, and overall fertility success.
