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Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
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Controlling cell growth and survival through regulated nutrient transporter expression

Aimee L Edinger1

  • 1Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2300, USA.

The Biochemical Journal
|July 25, 2007
PubMed
Summary

Mammalian cells regulate nutrient uptake via specific transporters. The target of rapamycin (TOR) pathway, particularly mTOR, controls transporter expression, impacting cell growth, proliferation, and potentially tumor suppression.

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