Pediatricians' adherence to pneumococcal conjugate vaccine shortage recommendations in 2 national shortages

Gerry Fairbrother1, Karen Broder, Mary Allen Staat

  • 1Center for Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, MLC 7014, Cincinnati, OH 45229-3039, USA. gerry.fairbrother@cchmc.org

Pediatrics
|July 25, 2007
PubMed

Insights

Pediatricians improved adherence to deferring pneumococcal conjugate vaccine doses for healthy children during shortages. However, severe shortages led to non-vaccination of high-risk children, highlighting policy gaps.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccine Supply Chain Management
  • Public Health Policy

Background:

  • Heptavalent pneumococcal conjugate vaccine (PCV7) shortages have impacted pediatric immunization schedules.
  • Understanding pediatrician experiences and adherence to recommendations during shortages is crucial for public health preparedness.

Purpose of the Study:

  • To compare pediatrician experiences and adherence to PCV7 shortage recommendations across two distinct shortage periods.
  • To identify factors influencing nonadherence to recommendations during the second PCV7 shortage.
  • To gauge pediatrician opinions on national immunization policies during vaccine shortages.

Main Methods:

  • A survey was administered to pediatrician immunization providers in the greater Cincinnati metropolitan area.
  • Data collected included PCV7 supply, immunization practices during shortages, and provider attitudes toward shortage policies.

Main Results:

  • High rates of PCV7 shortages were reported by 86% (first) and 84% (second) of pediatricians.
  • Adherence to deferring the fourth PCV7 dose for healthy children significantly increased from 62% to 89% between shortages.
  • Adherence to administering the fourth dose to high-risk children remained low (43% to 45%), with severe shortages linked to non-vaccination of this group.

Conclusions:

  • Adherence to PCV7 deferral recommendations for healthy children improved over time.
  • Severe PCV7 shortages negatively impacted the vaccination of high-risk children, indicating a need for improved supply chain strategies.
  • Pediatricians largely supported national vaccine shortage recommendations for liability protection.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...