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Tumor models in drug development.

D P Griswold1, S D Harrison

  • 1Southern Research Institute, Birmingham, Alabama.

Cancer Metastasis Reviews
|October 11, 1991
PubMed
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This review examines the evolution of anticancer drug screening methods. Current practices are shifting towards developing selective drugs for solid tumors due to a lack of effective treatments.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Discovery

Background:

  • Anticancer drug screening has a long history.
  • Traditional screening methods have limitations in identifying effective treatments for solid tumors.

Purpose of the Study:

  • To review the historical development of anticancer drug screening.
  • To evaluate current screening practices and models.
  • To reflect on the shift towards developing histotype-selective anticancer drugs.

Main Methods:

  • Historical review of anticancer drug screening.
  • Analysis of changes in drug discovery emphasis.
  • Evaluation of current model tumor systems and screening practices.

Main Results:

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  • A significant shift in drug discovery has influenced anticancer screening.
  • New model tumor systems are being developed.
  • Emphasis is now on drugs selective for specific tumor histotypes, particularly solid tumors.

Conclusions:

  • The current approach to anticancer drug discovery and screening is experimental.
  • The success of this new direction in developing selective drugs for solid tumors remains to be determined.