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The association between cognition and functional outcome in first-episode patients with schizophrenia: mystery
R van Winkel1, I Myin-Germeys, M De Hert
1University Psychiatric Center Catholic University Leuven, Leuvensesteenweg, Kortenberg, Belgium.
Objective:
The presence of a prospective association between cognition and functional outcome in first episode patients with schizophrenia is much debated.
Method:
Associations between Intelligence Quotient (IQ) measures and functional outcome were assessed at the first hospitalization and after 10 years follow-up.
Results:
Functional outcome was associated with estimated premorbid IQ and IQ at 10-year follow-up, but not with IQ assessed at first hospitalization.
Conclusion:
The presence of a prospective as well as a cross-sectional relationship of the global cognitive measure IQ with 10-year functional outcome could be established. However, assessing associations between cognitive measures assessed at first hospitalization and subsequent functional outcome, can give inconclusive results due to non-uniform intellectual deterioration from premorbid level in the period preceding the first hospitalization.
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