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(HX)n repeats: a pH-controlled protein-protein interaction motif of eukaryotic transcription factors?
R Janknecht1, C Sander, O Pongs
1Institut für Molekularbiologie, Medizinische Hochschule Hannover, Germany.
FEBS Letters
|December 16, 1991
Abstract:
A characteristic sequence repeat of type His-X, repeated several times in a row, is present in several eukaryotic transcription factors, e.g. HPHAHPHP in paired protein. Detailed molecular modelling and database searches lead to the suggestion that (HX)n repeats can mediate interaction between transcription factors in a pH-controlled fashion.