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Multifocal visual evoked potential and automated perimetry abnormalities in strabismic amblyopes
Vivienne C Greenstein1, Howard M Eggers, Donald C Hood
1Department of Ophthalmology, Columbia University, New York, New York, USA.
Summary
Standard automated perimetry (SAP) and multifocal visual evoked potential (mfVEP) both detect visual field deficits in strabismic amblyopes. mfVEP identified more abnormalities, including in fellow eyes, and showed shorter latencies in amblyopic eyes.
Area of Science:
- Ophthalmology
- Neuroscience
- Visual Science
Background:
- Strabismic amblyopia is a common cause of reduced visual acuity.
- Assessing visual field function in amblyopia is crucial for understanding its impact.
Purpose of the Study:
- To compare the diagnostic capabilities of standard automated perimetry (SAP) and multifocal visual evoked potential (mfVEP) in detecting visual field abnormalities in strabismic amblyopes.
- To evaluate the extent and nature of visual field deficits in both amblyopic and fellow eyes.
Main Methods:
- 12 strabismic amblyopes underwent Humphrey 24-2 visual fields (HVF) and mfVEPs.
- Abnormalities were defined by clusters of points with specific p-values for both techniques.
- Analysis included amplitude and latency measurements for mfVEP.
Main Results:
- SAP showed significantly higher foveal thresholds and lower mean deviation values in amblyopic eyes.
- mfVEP identified abnormalities in 11 amblyopic eyes and 6 fellow eyes, exceeding SAP's detection.
- Deficits spanned central to mid-peripheral regions, with significantly decreased mfVEP latencies in amblyopic eyes.
Conclusions:
- Both SAP and mfVEP detect visual field deficits in strabismic amblyopia.
- mfVEP is more sensitive, revealing abnormalities in fellow eyes and a greater number of amblyopic eyes.
- Reduced mfVEP latencies in amblyopic eyes suggest altered visual pathway function.
