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Rapid asymmetric evolution of a dual-coding tumor suppressor INK4a/ARF locus contradicts its function

Radek Szklarczyk1, Jaap Heringa, Sergei Kosakovsky Pond

  • 1Centre for Integrative Bioinformatics, Vrije University, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands.

Proceedings of the National Academy of Sciences of the United States of America
|July 27, 2007
PubMed
Summary

The INK4a/ARF tumor suppressor locus, crucial for preventing cancer, evolves rapidly and unevenly. This unique dual-coding structure may explain why mutations in INK4a/ARF are so common in human cancers.

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