Related Experiment Video

Updated: Jul 13, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Risk factors associated with the death of patients hospitalized for juvenile systemic lupus erythematosus

M M M Faco1, C Leone, L M A Campos

  • 1Unidades de Reumatologia e Infectologia Pediátricas, Instituto da Criança, Departamento de Pediatria, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|July 27, 2007
PubMed

Insights

Severe sepsis significantly increases mortality risk in hospitalized juvenile systemic lupus erythematosus (JSLE) patients. Autopsies are crucial for accurate diagnosis, revealing discrepancies in 60% of cases.

Area of Science:

  • Pediatric Rheumatology
  • Critical Care Medicine
  • Pathology

Background:

  • Juvenile Systemic Lupus Erythematosus (JSLE) is a chronic autoimmune disease with significant morbidity and mortality.
  • Hospitalization for JSLE carries inherent risks, necessitating identification of key factors contributing to adverse outcomes.

Purpose of the Study:

  • To identify risk factors associated with mortality in hospitalized JSLE patients.
  • To evaluate the role of autopsy in determining causes of death in JSLE.

Main Methods:

  • Retrospective analysis of 71 JSLE patients with 169 hospitalizations between 1994-2003.
  • Comparison of clinical data and autopsy reports for patients who died during hospitalization.
  • Univariate, stratified, and multivariate logistic regression analyses to identify independent predictors of mortality.

Main Results:

  • The primary causes of hospitalization were JSLE activity with infection (52%) and isolated JSLE activity (44%).
  • Severe sepsis emerged as the strongest independent predictor of death (OR = 98), followed by high SLEDAI scores.
  • Autopsy revealed diagnostic discrepancies in 6 out of 10 cases, highlighting its importance.

Conclusions:

  • Severe sepsis is a critical determinant of mortality in hospitalized JSLE patients.
  • Autopsy plays a vital role in clarifying the cause of death and improving diagnostic accuracy in JSLE mortality cases.

Related Concept Videos

Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...