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Updated: Jul 13, 2026

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
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Sesquiterpene compounds from Inula viscosa.

Gianfranco Fontana1, Salvatore La Rocca, Salvatore Passannanti

  • 1Dipartimento di Chimica Organica, Università degli Studi di Palermo, Parco d'Orleans II, Italy.

Natural Product Research
|July 27, 2007
PubMed
Summary

Researchers isolated two new compounds, 2,5-dihydroxyisocostic acid and 2,3-dihydroxycostic acid, from Inula viscosa. Three known sesquiterpenes were also identified, with new spectroscopic data reported for two.

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Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Organic Chemistry

Background:

  • Inula viscosa (L.) Aiton is a plant species known for its diverse secondary metabolites.
  • Sesquiterpenes are a class of terpenoids with potential biological activities.
  • Isolation and structural elucidation of plant-derived compounds contribute to understanding chemical diversity.

Purpose of the Study:

  • To isolate and characterize chemical constituents from the acetone extract of Inula viscosa.
  • To identify novel compounds and report spectroscopic data for known compounds.
  • To contribute to the knowledge of Inula viscosa's phytochemical profile.

Main Methods:

  • Extraction of Inula viscosa using acetone.
  • Isolation of compounds using chromatographic techniques.

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  • Structural determination of new compounds via 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy, including proton (1H) and carbon (13C) NMR.
  • Reporting of 13C-NMR spectra for Isocostic acid and Tomentosin for the first time.
  • Main Results:

    • Isolation of two new compounds: 2,5-dihydroxyisocostic acid and 2,3-dihydroxycostic acid.
    • Isolation of three known sesquiterpene compounds: Isocostic acid, Carabrone, and Tomentosin.
    • Complete structural elucidation of the new compounds using advanced NMR techniques.
    • First-time reporting of 13C-NMR data for Isocostic acid and Tomentosin.

    Conclusions:

    • The study successfully identified five sesquiterpene compounds from Inula viscosa.
    • Two novel dihydroxycostic acid derivatives were discovered.
    • The reported NMR data expands the spectral information available for these natural products.