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Related Experiment Video

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Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

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Published on: July 9, 2016

Synemin expression in brain.

Yuji Mizuno¹, Jeffrey R Guyon, Koichi Okamoto

¹Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma, Japan. mizunoy@med.gunma-u.ac.jp

|July 27, 2007

Summary

Synemin proteins are found in mouse brain neurons, particularly in the midbrain and pons. Synemin expression decreases in mdx mice, suggesting a link to dystrophin expression in neural tissue.

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Area of Science:

Neuroscience
Muscle Biology

Background:

Synemin, including alpha- and beta-synemin, has known interactions in muscle tissue.
Two synemin transcripts are expressed in the brain, but their neural function is unclear.

Purpose of the Study:

To investigate the expression and localization of alpha- and beta-synemin in the brain.
To understand the role of synemin in neural tissue, especially in relation to dystrophin.

Main Methods:

In situ hybridization and immunohistochemical analyses were performed.
Expression patterns were examined in C57BL/6 and mdx (dystrophin null) mice brains.

Main Results:

Alpha- and beta-synemin transcripts and proteins colocalize in neurons, predominantly in the midbrain and pons.
Synemin did not colocalize with alpha-dystrobrevin-1 in the brain, unlike in muscle.
Synemin mRNA expression was reduced in mdx mice compared to controls.

Conclusions:

Synemin is expressed in specific neuronal populations within the brain.
Synemin's neural function may involve interactions with other dystrophin-associated proteins.
Synemin transcription appears to be dependent on dystrophin expression in neural tissues.