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Updated: Jul 13, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

[Apoptosis. Signaling network and changes of cell ion and water balance]

A V Shirokova

    Tsitologiia
    |July 28, 2007
    PubMed

    Insights

    This review explores how changes in ion balance, pH, and membrane potential drive apoptotic cell shrinkage. It details the ionic mechanisms and alterations in plasma membrane transporters and channels during apoptosis.

    Area of Science:

    • Cell Biology
    • Biochemistry
    • Physiology

    Context:

    • Apoptosis, or programmed cell death, is a fundamental biological process.
    • Cell shrinkage is a hallmark morphological feature of apoptosis.
    • The precise ionic mechanisms underlying apoptotic cell shrinkage are not fully elucidated.

    Purpose:

    • To review the alterations in ion balance, pH, and membrane potential during apoptosis.
    • To elucidate the ionic mechanisms contributing to apoptotic cell shrinkage.
    • To summarize recent findings on the role of plasma membrane ion transporters and channels in apoptosis.

    Summary:

    • Apoptosis involves significant shifts in monovalent ion balance, intracellular pH, and plasma membrane potential.
    • These ionic changes are intrinsically linked to the mechanism of apoptotic cell shrinkage.
    • The review highlights the dynamic regulation of ion channels and transporters during programmed cell death.

    Impact:

    • Provides a comprehensive overview of the ionic basis of apoptotic cell shrinkage.
    • Identifies key ion transport processes critical for apoptosis.
    • Offers insights into potential therapeutic targets for diseases involving dysregulated apoptosis.

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