Related Experiment Video
Updated: Jul 13, 2026
Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
[Effects of alligator Zhikegao on relieving cough dispelling phlegm and anti-inflammation]
Dong-Hui Xu1, Zhao-Zhang Luo, Xue-Ting Mei
1Lab. of Traditional Chinese Medicine and Marine Drugs, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. dong-huixu@yahoo.com.cn
Objective:
To research the effects of Alligator Zhikegao on relieving cough, dispelling phlegm and anti-inflammation.
Method:
The coughing tests in mice, the phenol red secreting tests in mice, ear edema tests in mice,and paw edema tests and subcutaneous cotton ball granuloma in rats were adopted for observing the related pharmacological effects of Alligator Zhikegao.
Result:
Alligator Zhikegao could obviously prolong the latent period and decrease the times of mouse coughing, and remarkably inhibit the mouse ear edema (P < 0.001), the rat paw edema and the hyperplasia of subcutaneous cotton ball granuloma in rats. Alligator Zhikegao 11.70 g x kg(-1) could significant improve the carbonic clearances of macrophages (P <0.05) and the hemolysin level in serum (P <0.01).
Conclusion:
Alligator Zhikegao has significant effects on relieving cough, dispelling phlegm, anti-inflammation and immunological regulation.
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