Related Experiment Video
Updated: Jul 13, 2026
06:31
Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
[Lymphocele and kidney transplantation]
Róbert Langer1, András Tóth, Zsolt Máthé
1Semmelweis Egyetem, Altalános Orvostudományi Kar, Transzplantációs és Sebészeti Klinika, Budapest. roblanger@hotmail.com
Orvosi Hetilap
|July 28, 2007
Summary
Sirolimus-based immunosuppression in kidney transplant recipients increases the risk of lymphocele formation and the need for intervention. However, this regimen also significantly reduces the incidence of acute rejection episodes.
Area of Science:
- Nephrology
- Transplantation Immunology
- Surgical Complications
Background:
- Lymphocele is a known complication after kidney transplantation.
- This study investigates factors contributing to perinephric fluid collections and lymphoceles in sirolimus-treated patients.
Observation:
- Sirolimus-cyclosporine-prednisone regimen showed a higher incidence (38.1%) of perinephric fluid collections compared to cyclosporine-prednisone-azathioprine (17.6%).
- More patients on sirolimus required treatment for lymphoceles (15.8%) versus the conventional group (4.4%).
- Sirolimus-treated patients experienced a significantly lower rate of acute rejection episodes (21.4%) compared to the control group (54.2%).
Findings:
- The sirolimus-based immunosuppressive regimen is associated with a significantly higher incidence of lymphocele formation and a greater need for interventions like percutaneous drainage or surgery.
- Elevated serum creatinine levels were observed in both groups at the time of lymphocele diagnosis.
- Despite increased lymphocele complications, the sirolimus group demonstrated a substantially lower frequency of acute rejection.
Implications:
- Clinicians should be aware of the increased risk of lymphocele when using sirolimus in kidney transplant recipients.
- The findings suggest a trade-off between lymphocele risk and reduced acute rejection rates with sirolimus-based immunosuppression.
- Further research may explore strategies to mitigate lymphocele formation in patients receiving sirolimus.
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