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Related Experiment Videos

Patch testing with Indian standard series.

G Narendra1, C R Srinivas

  • 1Department of Dermatology and Venereology, PSG Institute of Medical Science & Research, Peelamedu Coimbatore-641 004, India.

Indian Journal of Dermatology, Venereology and Leprology
|July 28, 2007
PubMed
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Indian Standard Series (ISS) patch testing identified common allergens in 44% of patients with suspected allergic contact dermatitis. Nickel sulfate and potassium dichromate were the most frequent sensitizers, highlighting key differences from European standards.

Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis Research

Background:

  • Allergic contact dermatitis (ACD) is a significant public health concern.
  • Standardized patch testing is crucial for diagnosing ACD.
  • Existing standard series may not fully represent regional allergen prevalence.

Purpose of the Study:

  • To evaluate the efficacy of the Indian Standard Series (ISS) in identifying common allergens in patients with suspected ACD.
  • To compare the allergen profile identified by ISS with that of the European Standard Series.

Main Methods:

  • One hundred patients with suspected ACD underwent patch testing using the ISS.
  • Patient demographics (61 males, 39 females) were recorded.
  • Positive reactions were analyzed to identify frequent sensitizers.

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Main Results:

  • Forty-four percent of patients showed one or more positive reactions to the ISS.
  • The most frequent sensitizers were nickel sulfate (15%), potassium dichromate (13.75%), cobalt chloride and colophony (8.75% each), and fragrance mix and thiuram mix (7.5% each).
  • The ISS includes allergens like propylene glycol and gentamicin, while excluding others found in the European Standard Series, such as sesquiterpene lactone mix.

Conclusions:

  • The ISS is effective in identifying common allergens in Indian patients with suspected ACD.
  • Nickel sulfate and potassium dichromate are prevalent sensitizers in this population.
  • Differences in allergen composition between ISS and European Standard Series underscore the need for geographically relevant diagnostic tools.