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[Regression in primary cutaneous melanoma is not predictive for sentinel lymph node micrometastasis]
A Alquier-Bouffard1, F Franck, J Joubert-Zakeyh
1Service de Dermatologie, Université d'Auvergne Clermont-Ferrand 1, CHU, Hôtel-Dieu, Clermont-Ferrand.
Background:
The predictive value of regression in melanoma is debated.
Aim Of The Study:
A retrospective single-centre study to evaluate the correlation between regression in primary skin tumor and the presence of micrometastases in sentinel lymph nodes.
Patients And Methods:
Histological signs of regression in 84 melanomas (>1 mm) with corresponding sentinel lymph nodes were studied by two independent pathologists.
Results:
Regression was seen in 40 skin melanoma tumors while micrometastasis was seen in 24. Of the tumors with micrometastasis, only 10 were regressive (RR: 0.47, p=0.49). Breslow value>2 mm and male sex were predictive for node micrometastasis (RR: 4.6, p=0.03 and RR: 7.6, p=0.006, respectively). On multivariate analysis, these two factors were independent.
Comments:
These data suggest that regression in primary cutaneous melanoma is not predictive for lymph node metastasis.
