Probe-guided localization of cancer deposits using [18F]fluorodeoxyglucose

Area of Science:

• Nuclear medicine
• Surgical oncology
• Medical instrumentation

Background:

• Intraoperative detection of tumour tissue is crucial for complete resection.
• Existing methods face challenges in the low-contrast operating room environment.
• [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) offers a potential imaging solution.

Purpose of the Study:

• To review the capabilities of intraoperative tumour detection probes using [18F]FDG.
• To discuss factors affecting tumour-to-background contrast in the operating room.
• To evaluate radiation exposure for personnel.

Main Methods:

• Review of existing and prototype gamma and beta probes for [18F]FDG detection.
• Analysis of technical and biological factors influencing tumour contrast.
• Evaluation of dosimetry data for [18F]FDG administration prior to surgery.

Main Results:

• Several probes demonstrate sensitivity for 511 keV photons and beta particles from [18F]FDG.
• Tumour detection is challenged by the low-contrast operating room setting.
• Radiation doses to personnel appear acceptable.

Conclusions:

• Intraoperative [18F]FDG probes offer a promising tool for tumour detection.
• Optimizing contrast and probe design are key for clinical success.
• Current data suggest safe radiation exposure levels for surgical teams.