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Published on: April 1, 2015
The coagulation system in endocrine disorders: a narrative review
A Squizzato1, V E A Gerdes, W Ageno
1Department of Clinical Medicine, University of Insubria, Varese, Italy. alexsquizzo@libero.it
Internal and Emergency Medicine
|July 28, 2007
Summary
Endocrine disorders significantly impact blood clotting. While overt hypothyroidism may cause bleeding, hyperthyroidism, hypercortisolism, and growth hormone issues might increase thrombotic risk, though more research is needed.
Area of Science:
- Endocrinology
- Hematology
Background:
- Endocrine disorders can disrupt the body's haemostatic balance.
- Abnormal hormone levels are linked to altered coagulation test results and unprovoked bleeding or thrombotic events.
Purpose of the Study:
- To review the influence of common endocrine disorders on the coagulation system.
- To discuss the clinical implications of these interactions.
Main Methods:
- Literature review focusing on thyroid dysfunction, hyper- and hypocortisolism, and growth hormone disturbances.
- Brief discussion of other endocrine disorders' effects on coagulation.
Main Results:
- Overt hypothyroidism is clearly associated with bleeding diathesis, primarily via acquired von Willebrand syndrome.
- Hyperthyroidism, hypercortisolism, and abnormal growth hormone levels may indicate a hypercoagulable state, but require further clinical studies.
- Pheochromocytoma, hyperprolactinaemia, and hyperaldosteronism also show described effects on coagulation.
Conclusions:
- Endocrine disorders can lead to both bleeding and thrombotic episodes.
- Understanding these links is crucial for managing patients with endocrine diseases and coagulation abnormalities.
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01:29The Endocrine System
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Thromboembolic Disorders
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